Maybe you got one of those find-your-ancestry kits over the holidays. You’ve sent off your awkwardly collected saliva sample, and you’re awaiting your results. If your experience is anything like that of me and my mom, you may find surprises — not the dramatic “switched at birth” kind, but results that are really different from what you expected.

My mom, Carmen Grayson, taught history for 45 years, high school and college, retiring from Hampton University in the late 1990s. But retired history professors never really retire, so she has been researching her family’s migrations, through both paper records and now a DNA test. Her father was French Canadian, and her mother (my namesake, Gisella D’Appollonia) was born of Italian parents. They moved to Canada about a decade before my grandmother was born in 1909.
Last fall, we sent away to get our DNA tested by , the company that works with National Geographic. Mom’s results: 31 percent from Italy and Southern Europe. That made sense because of her Italian mother. But my Helix results didn’t even have an “Italy and Southern European” category. How could I have 50 percent of Mom’s DNA and not have any Italian? We do look alike, and she says there is little chance I was switched at birth with someone else.
We decided to get a second opinion and sent away to another company,  We opened our results together and were just as surprised. This time, I at least had a category for southern Europe. But Mom came back as 25 percent southern European, me only 6 percent. And the Italian? Mom had 11.3 percent to my 1.6. So maybe the first test wasn’t wrong. But how could I have an Italian grandmother and almost no Italian genes?
To answer this question, Mom and I drove up to Baltimore to visit  of the Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, who has spent his career studying genetics and human health.
“That’s surprising,” he told us when we showed him the results. “But it may still be in the limits of error that these methods have.”
The science for analyzing one’s genome is good, Chakravarti said. But the ways the companies analyze the genes leave lots of room for interpretation. So, he said, these tests “would be most accurate at the level of continental origins, and as you go to higher and higher resolution, they would become less and less accurate.”
As in my case — the results got me to Europe, just not Italy.
My 23andMe test also showed less than 1 percent of South Asian, Sub-Saharan African, and East Asian & Native American. This, Chakravarti said, is likely true because the genetics of people on a continental level are so different, and it’s not likely that South Asian will look like European. “Resolving a difference between, say, an African genome and an East Asian genome would be easy,” he said. “But resolving that same difference between one part of East Asia and another part of East Asia is much more difficult.”
I also learned that even though I got half of my genes from Mom, they may not mirror hers.
We do inherit our genes — 50 percent from each parent. But , a genetic counselor and the director of policy and clinical affairs of Helix, says a process called recombination means that each egg and each sperm carries a different mix of a parent’s genes.
“When we talk about the 50 percent that gets inherited from Mom, there’s a chance that you have a recombination that just gave you more of the northwest European part than the Italian part of your mom’s ancestry DNA,” she said. That is also why siblings can have different ancestry results.




The companies compare customers’ DNA samples to samples they have from people around the world who have lived in a certain area for generations. The samples come from some databases to which all scientists have access, and the companies may also collect their own.
“We’re able to look at, what are the specific markers, what are the specific segments of DNA that we’re looking at that help us to identify, ‘Those people are from this part of northern Europe or southern Europe or Southeast Asia,'” Levin said.
As the companies collect more samples, their understanding of markers of people of a particular heritage should become more precise. But for now, the smaller the percentage of a population within a continent that is in the database, the less certain they are. Helix chooses not to report some of those smaller percentages, Levin said.
The 23andMe company reports results with a 50 percent confidence interval — they’re 50 percent sure their geographic placement is correct. Move the setting up to 90 percent confidence, meaning your placement in a region is 90 percent certain, and that small 1.6 percent of my ancestry that is Italian disappears.
The ancestry tests also have to take into account the fact that humans have been migrating for millennia, mixing DNA along the way. To contend with that, the companies’ analyses involve some “random chance,” as Levin put it. A computer has to make a decision.
And the ancestry companies have to make judgment calls. , a senior product manager with 23andMe, said their computers compare the DNA with 31 groups. “Let’s say a piece of your DNA looks most like British and Irish, but it also looks a little bit like French-German,” he said. “Based on some statistical measures, we’d decide whether to call that as British-Irish or French-German, or maybe we go up one level and call it northwestern European.”
What does he think explains my case?
“It was a bit surprising,” he said. “But in looking at the fact that you have some southern European and some French-German, the picture became a little clearer to me.”
So, for now, my Italian grandmother doesn’t show up in these tests. No matter — Chakravarti, Levin and Smith all say to let the results add to your life story. The DNA is just a piece of what makes you you.
Gisele Grayson is a senior producer on NPR’s Science Desk who runs the health reporting collaboration with member stations and Kaiser Health News.
This <a target="_blank" href="/health-industry/my-grandmother-was-italian-why-arent-my-genes-italian/">article</a> first appeared on <a target="_blank" href="">Â鶹ŮÓÅ Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=807948&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Can a puppy video get you to buy health insurance through the Affordable Care Act exchanges? Florida Blue, a major insurer in that state, hopes the answer is yes.
“It’s hard to resist puppies, right? Let’s just be honest,” said Penny Shaffer, the insurer’s South Florida regional market president, who talked to WLRN’s Sammy Mack. In the target=”_blank” rel=”noopener”>video According to a Commonwealth Fund analysis, Hispanics have seen the in the number of people insured of any ethnic group since the Affordable Care Act was passed. One ZIP code in the heart of Miami’s Cuban district saw the most marketplace sign-ups of any ZIP code in the country a couple of years ago. And market research shows that Latina women are very active video sharers. [youtube= Open enrollment for health insurance on the Affordable Care Act exchanges started last week. For anywhere from six weeks to a few months, , people can buy plans on the individual markets for 2018. But the Trump administration has cut the ACA advertising budget by 90 percent, as well as money to pay navigators, people who help customers pick a plan and enroll. So, across the country, municipalities, insurers and grass-roots organizations are working even harder to get the word out that the ACA is still in place. That explains the puppies. California also sees Latinos as a key group for outreach, . The video strategy of , that state’s marketplace, is a little different, emphasizing how important insurance is for unexpected illness by telling the story of a young woman who needed a heart transplant. [youtube= In Phoenix, KJZZ’s Will Stone reported that the Arizona Public Interest Research Group is part of a grass-roots coalition advertising open enrollment. They are hoping to get younger people to sign up, because younger people tend to be healthier and less expensive. Insurance pools need young people to balance the expenses of older and sicker people. But Diane Brown, who heads Arizona PIRG, said consumer confusion over health insurance, complicated enough already, has been exacerbated by the political wrangling over the ACA this year. Pennsylvania’s insurance commissioner’s office is spending some of its department’s budget on education, including setting up to help guide consumers through how to pick a plan, reported Elana Gordon from WHYY. And in Tennessee, Blake Farmer of Nashville Public Radio said that even though the navigator budget was cut, it was cut only by 15 percent and the state found enough savings in other places to Moving along to Texas, KUT’s Ashley Lopez found that in the bigger cities, local taxpayers are filling in the gap. Austin is spending a lot more money this year on outreach efforts. Michelle Tijerina works for , which provides health care for low-income people in Travis County and is funded by local property taxes. “We will have ads on radio — English and Spanish. We will be on Facebook. We will have Google ads and banners. We will be out in the community, talking to schools,” Tijerina said. Tijerina said Central Health is also hiring twice as many people this year to help folks sign up once enrollment starts. This story is part of a reporting partnership with NPR, local member stations and . This <a target="_blank" href="/insurance/insurer-tries-a-soft-touch-puppies-for-this-years-hard-sell-of-obamacare-plans/">article</a> first appeared on <a target="_blank" href="">Â鶹ŮÓÅ Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
Maybe you got one of those find-your-ancestry kits over the holidays. You’ve sent off your awkwardly collected saliva sample, and you’re awaiting your results. If your experience is anything like that of me and my mom, you may find surprises — not the dramatic “switched at birth” kind, but results that are really different from what you expected.

My mom, Carmen Grayson, taught history for 45 years, high school and college, retiring from Hampton University in the late 1990s. But retired history professors never really retire, so she has been researching her family’s migrations, through both paper records and now a DNA test. Her father was French Canadian, and her mother (my namesake, Gisella D’Appollonia) was born of Italian parents. They moved to Canada about a decade before my grandmother was born in 1909.
Last fall, we sent away to get our DNA tested by , the company that works with National Geographic. Mom’s results: 31 percent from Italy and Southern Europe. That made sense because of her Italian mother. But my Helix results didn’t even have an “Italy and Southern European” category. How could I have 50 percent of Mom’s DNA and not have any Italian? We do look alike, and she says there is little chance I was switched at birth with someone else.
We decided to get a second opinion and sent away to another company,  We opened our results together and were just as surprised. This time, I at least had a category for southern Europe. But Mom came back as 25 percent southern European, me only 6 percent. And the Italian? Mom had 11.3 percent to my 1.6. So maybe the first test wasn’t wrong. But how could I have an Italian grandmother and almost no Italian genes?
To answer this question, Mom and I drove up to Baltimore to visit  of the Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, who has spent his career studying genetics and human health.
“That’s surprising,” he told us when we showed him the results. “But it may still be in the limits of error that these methods have.”
The science for analyzing one’s genome is good, Chakravarti said. But the ways the companies analyze the genes leave lots of room for interpretation. So, he said, these tests “would be most accurate at the level of continental origins, and as you go to higher and higher resolution, they would become less and less accurate.”
As in my case — the results got me to Europe, just not Italy.
My 23andMe test also showed less than 1 percent of South Asian, Sub-Saharan African, and East Asian & Native American. This, Chakravarti said, is likely true because the genetics of people on a continental level are so different, and it’s not likely that South Asian will look like European. “Resolving a difference between, say, an African genome and an East Asian genome would be easy,” he said. “But resolving that same difference between one part of East Asia and another part of East Asia is much more difficult.”
I also learned that even though I got half of my genes from Mom, they may not mirror hers.
We do inherit our genes — 50 percent from each parent. But , a genetic counselor and the director of policy and clinical affairs of Helix, says a process called recombination means that each egg and each sperm carries a different mix of a parent’s genes.
“When we talk about the 50 percent that gets inherited from Mom, there’s a chance that you have a recombination that just gave you more of the northwest European part than the Italian part of your mom’s ancestry DNA,” she said. That is also why siblings can have different ancestry results.




The companies compare customers’ DNA samples to samples they have from people around the world who have lived in a certain area for generations. The samples come from some databases to which all scientists have access, and the companies may also collect their own.
“We’re able to look at, what are the specific markers, what are the specific segments of DNA that we’re looking at that help us to identify, ‘Those people are from this part of northern Europe or southern Europe or Southeast Asia,'” Levin said.
As the companies collect more samples, their understanding of markers of people of a particular heritage should become more precise. But for now, the smaller the percentage of a population within a continent that is in the database, the less certain they are. Helix chooses not to report some of those smaller percentages, Levin said.
The 23andMe company reports results with a 50 percent confidence interval — they’re 50 percent sure their geographic placement is correct. Move the setting up to 90 percent confidence, meaning your placement in a region is 90 percent certain, and that small 1.6 percent of my ancestry that is Italian disappears.
The ancestry tests also have to take into account the fact that humans have been migrating for millennia, mixing DNA along the way. To contend with that, the companies’ analyses involve some “random chance,” as Levin put it. A computer has to make a decision.
And the ancestry companies have to make judgment calls. , a senior product manager with 23andMe, said their computers compare the DNA with 31 groups. “Let’s say a piece of your DNA looks most like British and Irish, but it also looks a little bit like French-German,” he said. “Based on some statistical measures, we’d decide whether to call that as British-Irish or French-German, or maybe we go up one level and call it northwestern European.”
What does he think explains my case?
“It was a bit surprising,” he said. “But in looking at the fact that you have some southern European and some French-German, the picture became a little clearer to me.”
So, for now, my Italian grandmother doesn’t show up in these tests. No matter — Chakravarti, Levin and Smith all say to let the results add to your life story. The DNA is just a piece of what makes you you.
Gisele Grayson is a senior producer on NPR’s Science Desk who runs the health reporting collaboration with member stations and Kaiser Health News.
This <a target="_blank" href="/health-industry/my-grandmother-was-italian-why-arent-my-genes-italian/">article</a> first appeared on <a target="_blank" href="">Â鶹ŮÓÅ Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=807948&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Can a puppy video get you to buy health insurance through the Affordable Care Act exchanges? Florida Blue, a major insurer in that state, hopes the answer is yes.
“It’s hard to resist puppies, right? Let’s just be honest,” said Penny Shaffer, the insurer’s South Florida regional market president, who talked to WLRN’s Sammy Mack. In the target=”_blank” rel=”noopener”>video According to a Commonwealth Fund analysis, Hispanics have seen the in the number of people insured of any ethnic group since the Affordable Care Act was passed. One ZIP code in the heart of Miami’s Cuban district saw the most marketplace sign-ups of any ZIP code in the country a couple of years ago. And market research shows that Latina women are very active video sharers. [youtube= Open enrollment for health insurance on the Affordable Care Act exchanges started last week. For anywhere from six weeks to a few months, , people can buy plans on the individual markets for 2018. But the Trump administration has cut the ACA advertising budget by 90 percent, as well as money to pay navigators, people who help customers pick a plan and enroll. So, across the country, municipalities, insurers and grass-roots organizations are working even harder to get the word out that the ACA is still in place. That explains the puppies. California also sees Latinos as a key group for outreach, . The video strategy of , that state’s marketplace, is a little different, emphasizing how important insurance is for unexpected illness by telling the story of a young woman who needed a heart transplant. [youtube= In Phoenix, KJZZ’s Will Stone reported that the Arizona Public Interest Research Group is part of a grass-roots coalition advertising open enrollment. They are hoping to get younger people to sign up, because younger people tend to be healthier and less expensive. Insurance pools need young people to balance the expenses of older and sicker people. But Diane Brown, who heads Arizona PIRG, said consumer confusion over health insurance, complicated enough already, has been exacerbated by the political wrangling over the ACA this year. Pennsylvania’s insurance commissioner’s office is spending some of its department’s budget on education, including setting up to help guide consumers through how to pick a plan, reported Elana Gordon from WHYY. And in Tennessee, Blake Farmer of Nashville Public Radio said that even though the navigator budget was cut, it was cut only by 15 percent and the state found enough savings in other places to Moving along to Texas, KUT’s Ashley Lopez found that in the bigger cities, local taxpayers are filling in the gap. Austin is spending a lot more money this year on outreach efforts. Michelle Tijerina works for , which provides health care for low-income people in Travis County and is funded by local property taxes. “We will have ads on radio — English and Spanish. We will be on Facebook. We will have Google ads and banners. We will be out in the community, talking to schools,” Tijerina said. Tijerina said Central Health is also hiring twice as many people this year to help folks sign up once enrollment starts. This story is part of a reporting partnership with NPR, local member stations and . This <a target="_blank" href="/insurance/insurer-tries-a-soft-touch-puppies-for-this-years-hard-sell-of-obamacare-plans/">article</a> first appeared on <a target="_blank" href="">Â鶹ŮÓÅ Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">