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Weight loss and cardiometabolic benefits were fully reversed within 2 years for people who stopped weight management medications, a systematic review and meta-analysis showed. (Monaco, 1/7)

Arrowhead Pharmaceuticals said Tuesday that its gene-silencing candidates helped people with obesity lose fat, very early results that could intensify the competition among biotechs to develop longer-lasting weight loss drugs. (Chen, 1/6)

Very high lipoprotein(a) levels strongly predicted long-term cardiovascular disease risk in healthy women, according to a cohort study, while mild to moderately high levels were not really red flags. Contemporary guidelines do not generally endorse universal screening. (Lou, 1/7)

Previous research has shown that small amounts of rifampin, the most powerful antibiotic against TB, can reach the brain. But those studies did not explore the link between higher doses of rifampin and reduced mortality. (Bergeson, 1/7)

Adding a daily fish oil supplement to psychotherapy showed no significant benefit over placebo for kids and teens with moderate-to-severe major depressive disorder (MDD), a randomized trial showed. (Monaco, 1/2)