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Friday, Sep 2 2016

Full Issue

Exuberance Over Immunotherapy Has Dimmed Amid Recent Setbacks

The field was blazing hot a year ago, but some of that optimism has faded as companies and scientists trying to use immunotherapy have been blocked by daunting challenges.

The idea is tantalizing: Reengineer a patient鈥檚 own immune cells to attack the cancer that鈥檚 killing her. Scientists have proven it can be done, curing patients of otherwise terminal blood cancers. But faith in this approach, dubbed CAR-T immunotherapy, has been shaken聽in recent months. First, Juno Therapeutics, a leader in the field, announced that four patients in its clinical trials had died.聽Then, just this week, Novartis 鈥 one of the prime contenders in the race to commercialize CAR-T therapy 鈥 shuttered its cell and gene therapy unit and announced plans to lay off 120 employees. (Keshavan, 9/2)

Bald but beaming, 5-year-old Eden Oyelola yanked the long rope to ring the 鈥渧ictory bell鈥 at Children鈥檚 National Medical Center last September. She was finally done with her treatment for brain cancer 鈥 surgery followed by months of radiation and chemotherapy that made her terribly ill. At a 鈥渂ell party鈥 at her home in Upper Marlboro, Md., later that week, she gobbled down ice cream with friends and rode a pony around the back yard. Her parents exhaled in relief. 鈥淲e thought she was in the clear,鈥 her father said. The relief was short-lived. (McGinley, 9/1)

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