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Thursday, Oct 2 2025

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Genetic Analysis Finds Different Forms Of Autism, Study Shows

The study found that rather than being one single genetic condition, autism is instead a cluster of conditions with similar features. In other autism news: folate supplements vs. leucovorin; the dementia drug memantine may help a small subset of ASD youth with social functioning; and more.

People who learn they have autism after age 6 鈥 the current median age at diagnosis 鈥 are often described as having a 鈥渕ilder鈥 form of autism than people diagnosed as toddlers. A new study challenges that assumption. A genetic analysis finds that people with autism spectrum disorder diagnosed in late childhood or adolescence actually have 鈥渁 different form of autism,鈥 not a less severe one, said Varun Warrier, senior author of a study published Wednesday in Nature. (Szabo, 10/1)

That broadening of the diagnosis, autism experts believe, along with the increasing awareness of the disorder, is largely responsible for the steep rise in autism cases that Health Secretary Robert F. Kennedy Jr. has called 鈥渁n epidemic鈥 and has attributed to theories of causality that mainstream scientists reject, like vaccines and, more recently, Tylenol. And the diagnostic expansion has now become a flashpoint in a long-running debate over how autism should be defined, one that has divided parents and activists, ignited social media battles and grown fiercer with Mr. Kennedy鈥檚 laser focus on autism. (Ghorayshi, 10/1)

The Food and Drug Administration last week announced it would make it easier for parents to access leucovorin calcium to treat children with autism. Leucovorin is a form of vitamin B9 or folate, a nutrient essential for neurodevelopment. Though its effectiveness for autism treatment has only been researched in small studies, the announcement appeared to send some rushing to buy over-the-counter supplements with the same key ingredient as the drug Trump administration officials touted. Some online shops appeared to sell out of folinic acid supplements. (Malhi, 10/1)

Memantine hydrochloride, a noncompetitive NMDA receptor antagonist, may help improve social impairment in a specific subset of youth with autism spectrum disorder (ASD), a small trial suggested. (Monaco, 10/1)

In related news 鈥

Under Eric鈥檚 ID law, people with autism and other non-apparent disabilities can obtain a state-issued ID that is meant to alert law enforcement officers of their condition. (Munro, 10/1)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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