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Leading American and British cancer researchers are urging that all men with advanced prostate cancer strongly consider being tested for inherited gene mutations -- both to help steer their treatment and to alert family members who themselves might be at increased risk for a range of cancers. This new recommendation, which represents a major change in approach, was prompted by a study published Wednesday in the New England Journal of Medicine. The researchers found that almost 12 percent of men with advanced cancer had defects in genes that are designed to fix damage to DNA, compared to 4.6 percent of patients with disease that hadn't spread. (McGinley, 7/6)

Genomic Health Inc. has struck a deal to commercialize a new blood test that can help advanced prostate cancer patients decide whether to try costly new-generation drugs or rely on much cheaper traditional chemotherapy to improve their chances for survival. The test, developed by closely held Epic Sciences Inc., San Diego, detects a mutation associated with a poor response to two new drugs, Xtandi from Medivation Inc. and Astellas Pharma Inc. of Japan, and Zytiga from Johnson & Johnson. (Winslow, 7/7)

A high-priced prostate cancer drug discovered at UCLA is at the center of a multibillion-dollar takeover battle that has several giant pharmaceutical firms eyeing the purchase of San Francisco biotech firm Medivation. Medivation sells the drug Xtandi for about $129,000 a year. Earlier this year, two nonprofit groups asked the federal government to allow other companies to sell the drug at lower prices. The groups argued that the federal government had a right under the law to allow lower-priced competition because UCLA scientists had used taxpayer-funded grants to discover Xtandi. (Petersen, 7/6)