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The National Institutes of Health is overhauling the leadership of its flagship hospital after an independent review concluded that patient safety had become “subservient to research demands” on the agency’s sprawling Bethesda campus. The shake-up at the NIH Clinical Center, which was announced to staff Tuesday, represents the most significant restructuring at the nation’s premier biomedical research institution in more than half a century. (Sun, 5/10)

The National Institutes of Health is overhauling the leadership of its renowned research hospital in the wake of what it termed “quality and safety gaps” in the production of sterile drugs used in clinical studies there. The federal agency, based in Bethesda, Md., said it would name a new physician chief executive to run the hospital, which is known as the NIH Clinical Center. This new official will report to a newly selected hospital board. The clinical center treats patients from around the U.S. who have rare and often fatal diseases. (Burton, 5/10)

[NIH Director Dr. Francis Collins] said the months-long probe into the hospital’s practices — which found systemic problems with patient safety — marked “the darkest moments” of his seven years at the NIH, according to the [Washington] Post. (Ferris, 5/10)