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It was Joanna Acevedo’s psychiatrist who first raised the idea of a weight-loss drug. Since 2018, Ms. Acevedo has relied on antipsychotic medications to manage her bipolar disorder. The drugs kept her paranoia at bay — really, they kept her alive, she said. They also led her to gain 70 pounds. By age 26, she had become prediabetic. (Blum, 11/3)

The population benefit of COVID-19 vaccination via direct and indirect effects was substantial in Tokyo in early 2022 during Omicron, with an estimated 65% reduction in the number of SARS-CoV-2 infections, according to a new model that compared risks between unvaccinated and vaccinated individuals. (Soucheray, 11/6)

Implementation of an antimicrobial stewardship program (ASP) was associated with a significant reduction in antibiotic consumption and antimicrobial resistance in children with severe bacterial pneumonia at a pediatric intensive care unit (PICU) in China, researchers reported yesterday in the Journal of Global Antimicrobial Resistance. (Dall, 11/6)

A study of tuberculosis (TB) patients in South Africa found that more than half receiving treatment with a bedaquiline-containing regimen had isolates with bedaquiline resistance, researchers reported last week in The Lancet Microbe. (Dall, 11/6)