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San Francisco is ramping up its efforts to battle a deadly fentanyl crisis with the city's new mayor declaring a state of emergency because of the drug's impact. Mayor Daniel Lurie on Wednesday afternoon signed an ordinance declaring a fentanyl state of emergency to address the crisis after the city's Board of Supervisors approved the ordinance Tuesday evening. (Castañeda, 2/12)

Canada's newly appointed fentanyl czar says his goal is to bring the already low percentage of the deadly opioid smuggled south into the United States down to zero. "Getting the number to zero is in fact our goal and should be our goal," Kevin Brosseau told reporters Wednesday, his first full day in the position. (Tunney, 2/12)

The drug supply is constantly evolving, and some experts suggest that a “fourth wave” of the opioid epidemic is underway, in which illicit fentanyl is more frequently mixed with other drugs. New research shows high levels of one unexpected addition: BTMPS, an industrial chemical used as an adhesive in the production of plastics, was found in the illicit fentanyl supply in the US. (Mukherjee, 2/12)

VCU's John Freyer has spent years training students and residents how to use the life-saving overdose reversal spray to fight the opioid crisis. (Moreno, 2/13)

South Dakota Attorney General Marty Jackley highlights one illegal substance in particular when discussing marijuana laced with opioids or other drugs. “We have seen this before,” Jackley said Monday. “It’s not very common in relation to marijuana. We’ll oftentimes see it with heroin or other dangerous controlled substances, but we have seen it before with marijuana.” (Santella, 2/10)

A legal loophole is allowing children who access social media to see enticing advertisements for marijuana with potentially dangerous consequences, according to experts. (LaMotte, 2/12)

A small number of patients taking GLP-1 weight loss medications have experienced loss of vision, but researchers say they have not established a direct link to the drugs. A new study published in JAMA Opthalmology focused on patients using semaglutide, which is marketed under the brand names Wegovy and Ozempic, and tirzepatide, which is marketed as Mounjaro and Zepbound. (Whiteside, 2/12)

Yogurt has often been touted as good for gut health. Now, in a new study, researchers at Mass General Brigham in Boston have found it may be beneficial in the fight against cancer. The study released Wednesday found that people who ate two or more servings of yogurt per week tended to have lower rates of a particularly aggressive form of colorectal cancer. (Riley, 2/12)