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The safety of the monoclonal antibody nirsevimab and the effect of nirsevimab on hospitalizations for respiratory syncytial virus (RSV)–associated lower respiratory tract infection when administered in healthy infants are unclear. (Drysdale, et al, 12/28)

A study of US patients hospitalized with gram-negative bloodstream infections (GN-BSIs) found that fewer than half of those eligible were transitioned from intravenous (IV) to oral antibiotic therapy. (Dall, 1/2)

Implementation of a diagnostic stewardship intervention for suspected pneumonia at a Michigan hospital was associated with a reduction in positive respiratory cultures and broad-spectrum antibiotic use, researchers reported last week in Clinical Microbiology and Infection. (Dall, 1/2)

Scientists develop a new, high-resolution technique for finding potential therapeutic targets on proteins in living cells. The findings could lead to more targeted therapeutics for nearly any human disease. (Scripps Research Institute, 1/2)

Only 4.5% of a cohort of pediatric COVID-19 patients admitted to US hospitals during the period of Omicron predominance had completed their primary COVID-19 vaccine series, and 7.0% had started but didn't finish the series, The Pediatric Infectious Disease Journal reports. (Van Beusekom, 12/29)